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Background  Canine otitis externa is a painful condition which can be challenging to treat due to difficulties in the administration of otic medication. This can be due to lack of owner compliance in the application of ear drops or due to the resentment that some dogs demonstrate when attempts are made to administer topical medication into a sensitive ear canal. The aim of the study was to assess the efficacy of a topical LED-illuminated gel ( LIG ) in canine otitis externa in comparison to standard of care therapy. Dogs with spontaneous otitis externa were randomly allocated in three groups: groups QW received  LIG  once weekly; BW received  LIG  twice weekly; group C received enrofloxacin and silver sulfadiazine twice daily.  LIG  consists of a topical application of a gel containing chromophores that, when illuminated by a LED lamp, re-emit fluorescent light which can stimulate physiological responses, promoting healing and controlling bacteria. The evaluation protocol (T 0  to T 5 ) considered clinical assessment (OTIS-3-index-scoring-system; pruritus-severity-scale; pain-severity-score; aural temperature), cytological scoring system, quali-quantitative bacteriologic assessment.    Results  All groups (QW,  n  = 21; BW,  n  = 23; C,  n  = 20) showed improvement during the study (QW:  P  < 0.02 for cytological and pain scores,  P  < 0.003 for bacteriologic assessment,  P  < 10 − 4  for pruritus, total OTIS-3 and temperature assessments; BW:  P  < 10 − 4  for all clinical, cytological and bacteriologic assessments; C:  P  < 0.02 for all clinical and cytological assessments,  P  < 10 − 4  for bacteriologic assessment). The highest clinical score reduction occurred in Group BW ( P  < 0.014 in T 3 ;  P  < 0.001 in T 4  and  P  < 10 − 4  in T 5 ). BW reached the clinically relevant effect level at T 3  (− 3.26 ± 1.21 levels), QW reached it at T 4  (− 3.24 ± 0.99), C did not reach it. No differences between groups were seen in the reduction of CFU/mL (T 0 -T 5 ).    Conclusions  All treatment groups showed a positive clinical effect.  LIG  administered twice-a-week was the most favourable protocol of the study.  LIG  may be considered beneficial in the management of canine otitis externa; it seems to be effective in controlling the clinical condition, including the signs of inflammation and local pain, the bacterial growth, and it may help increasing treatment compliance.

Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs