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Background   Toxoplasma gondii , an intracellular apicomplexan protozoan parasite, can infect almost all warm-blooded animals. The aim of the present study was to investigate  T. gondii  oocyst-driven infection in pigs, chickens and humans in Jilin province, northeastern China.    Results  The serum samples of pigs, chickens and humans were sampled and tested by indirect enzyme-linked immunosorbent assays (ELISAs) using dense granule antigen GRA7, oocyst-specific protein OWP8, and sporozoite-specific protein CCp5A, respectively. Results showed a prevalence of 16.7% by GRA7-ELISA, and 12.2% by OWP8- and CCp5A-ELISA in pigs; 10.4% by GRA7-ELISA, 13.5% by OWP8-ELISA, and 9.4% by CCp5A-ELISA in chickens; and 14.2% by GRA7-ELISA, 3.6% by OWP8-ELISA, and 3.0% by CCp5A-ELISA in humans. No significant differences were observed between  T. gondii  seroprevalence in pigs and chickens among the three antigens-based ELISAs ( P  > 0.05). However, there were significant differences between  T. gondii  seroprevalence rates in humans ( P  < 0.05). These findings demonstrated a low prevalence of  T. gondii  oocyst-driven infection in humans, a medium prevalence in pigs, and a high prevalence in chickens.    Conclusions  The present study demonstrated that different oocyst-driven infection rates in different animal species, which would help to design effective strategies to prevent  T. gondii  transmission. To our knowledge, this is the first study to differentiate  T. gondii  infective forms in pigs, chickens and humans in China.

Toxoplasma gondii oocyst-driven infection in pigs, chickens and humans in northeastern China