English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Probiotics are important for pigs to enhance health and intestinal development, which are potential alternative to antibiotics. Many studies have reported the functions of single bacterial strain as probiotic on the animals. In this study, we evaluated effects of combined probiotics on growth performance, inflammation and intestinal microbiota in weaned pigs. One hundred and eight pigs, weaned at 28 day old (7.12 ± 0.08 kg), were randomly divided into the 3 dietary treatments with 6 pens and 6 pigs per pen (half male and half female). The experimental period lasted for 28 days and treatments were as follows: i. Control: basal diet; ii. Antibiotic: the basal diet plus 75 mg· kg − 1  chlortetracycline; and iii. Probiotics: basal diet plus 4% compound probiotics.    Results  Supplementation probiotics improved average daily gain over the entire 28 days ( P  < 0.01) and feed efficiency in the last 14 days ( P  < 0.05) compared with the other two groups. Both probiotics and antibiotic supplementation decreased concentrations of serum pro-inflammatory cytokines interleukin-6 ( P  < 0.05) and interferon-γ ( P  < 0.01). Probiotics group had greater abundance of  Lactobacillus  in the caecal digesta and Firmicutes in the colonic digesta, while both probiotics and antibiotic supplementation inhibited  Treponema_2  and  Anaerovibrio  in the caecal digesta. Caecal acetic and propionic acid ( P  < 0.05) of probiotics group were higher than the other two groups, whereas concentrations of colonic lactic acid and propionic acid ( P  < 0.05) of antibiotic group were lower than control and probiotics groups.    Conclusions  These findings suggest that combined supplementation of  Lactobacillus fermentum  and  Pediococcus acidilactici  regulate the gut health and improve the host ADG and F/G by decreasing serum pro-inflammatory factors (IL-6, IFN-γ), promoting beneficial bacteria ( Lactobacillus  in the caecal digesta and Firmicutes in the colonic digesta), enhancing production of short chain fatty acids, and inhibiting pathogens ( Treponema_2, Anaerovibrio  in the caecal digesta).    Electronic supplementary material  The online version of this article (10.1186/s12917-019-1991-9) contains supplementary material, which is available to authorized users.

bmc veterinary research

Combined supplementation of Lactobacillus fermentum and Pediococcus acidilactici promoted growth performance, alleviated inflammation, and modulated intestinal microbiota in weaned pigs