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Background  Haemonchosis affects sheep husbandry and its treatment is often compromised due to the development of anthelminthic resistance. Plant-derived bioactive compounds have been studied as alternative to control  Haemonchus contortus . The objective of this study was to evaluate the effect of  Senecio brasiliensis  extracts on  H. contortus  egg hatching and infective larvae migration.    Results  The aqueous extract from dried and fresh plant and alkaloid-enriched fraction of the previously dried leaves of  S. brasiliensis  inhibited  H. contortus  egg hatching. The main plant compound in alkaloid fraction was integerrimine, a pyrrolizidine alkaloid (PA). However, the aqueous extract from dried plant displayed higher efficacy when compared to their alkaloid enriched or non-polar fractions, meaning that, although PAs contributed to the ovicidal effect, other compounds in the plant can also contribute to their effect. Furthermore, the aqueous extract from dried plant also had higher efficacy than aqueous extract from fresh plant in larvae migration inhibition. Finally, extract from dried plant presented low in vitro cytotoxic effect.    Conclusion  Taken together our results suggest a good anthelmintic effect of  S. brasiliensis , especially when aqueous extract is prepared from dried plant. Further in vivo studies should be performed focused on forms of administration of this extract in rearing sheep.

In vitro ovicidal effect of a Senecio brasiliensis extract and its fractions on Haemonchus contortus