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Background  Urban rodents and house shrews are closely correlated in terms of location with humans and can transmit many pathogens to them. Hepatitis E has been confirmed to be a zoonotic disease. However, the zoonotic potential of rat HEV is still unclear. The aim of this study was to determine the prevalence and genomic characteristics of hepatitis E virus (HEV) in rodents and house shrews.    Results  We collected a total of 788 animals from four provinces in China. From the 614 collected murine rodents, 20.19% of the liver tissue samples and 45.76% of the fecal samples were positive for HEV. From the 174 house shrews ( Suncus murinus ), 5.17% fecal samples and 0.57% liver tissue samples were positive for HEV. All of the HEV sequences obtained in this study belonged to  Orthohepevirus  C1. However, we observed a lower percentage of identity in the ORF3 region upon comparing the amino acid sequences between  Rattus norvegicus  and  Rattus losea . HEV derived from house shrews shared a high percentage of identity with rat HEV. Notably, the first near full-length of the HEV genome from  Rattus losea  is described in our study, and we also report the first near full-length rat HEV genomes in  Rattus norvegicus  from China.    Conclusion  HEV is prevalent among the three common species of murine rodents ( Rattus. norvegicus ,  Rattus. tanezumi , and  Rattus. losea ) in China. HEV sequences detected from house shrews were similar to rat HEV sequences. The high identity of HEV from murine rodents and house shrews suggested that HEV can spread among different animal species.    Electronic supplementary material  The online version of this article (10.1186/s12917-018-1746-z) contains supplementary material, which is available to authorized users.

The prevalence and genomic characteristics of hepatitis E virus in murine rodents and house shrews from several regions in China