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Background  It is known that the bovine fetus can mount an immune and inflammatory reaction to infection, but it is not known whether there is a contemporaneous maternal response. Nor is it known whether the response of calves which die perinatally, with or without infection, differs from that of live perinates. Hence, the objective of this study was to determine if acute phase reactant and immunoglobulin concentrations differed between calves (and their dams) in three groups: live calves (CC;  n  = 21) and dead calves with (PM INF+;  n  = 22) or without (PM INF-;  n  = 89) in utero infection. In calf plasma, serum amyloid A, haptoglobin, immunoglobulins M, G 1  and G 2  and interleukin-6 were measured. In dam serum, SAA and Hp was measured and in amniotic and abomasal fluid, IL-6 was measured.    Results  Live calves had higher plasma concentrations of SAA and IL-6 than dead calves with (PM INF+) or without (PM INF-) in utero infection. Calves in the PM INF-, but not PM INF+ group, had higher Hp concentrations than calves in the CC group. Calves in the PM INF+ group had higher IgG 1  concentrations than calves in the PM INF- and CC groups. Except for higher IgG 1  and IgG 2  concentrations, biomarker values did not differ significantly between dead calves with or without in utero infection. Live calves had higher IL-6 concentrations in abomasal fluid compared to PM INF- calves. There were no significant differences in blood biomarker concentrations between dams of the three groups of calves. Amniotic fluid IL-6 concentrations were higher from the dams of control calves than the dams of uninfected calves.    Conclusions  Differences in biomarkers (higher Hp and IgG 1 ; lower SAA and IL-6) between perinatal mortalities and live perinates probably reflect differences between these two groups in age at sampling (SAA and IL-6) and in utero infection (IgG 1 ). Out of the six analytes measured in calves, only IgG 1  and IgG 2  were biomarkers of (chronic) in utero infection.

Perinatal immuno/inflammatory responses in the presence or absence of bovine fetal infection