English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Maytenus senegalensis  is a common shrub which is scattered in tropical Africa. Different parts of this plant have been reported to be useful in traditional medicine against gastrointestinal disorders and intestinal worms. This study evaluated the anthelmintic activity of the aqueous stem bark extract of  M. senegalensis  using egg hatch assay (EHA), larval migration inhibition assay (LMIA) and adult worms’ motility inhibition assay (AMIA).    Results  On EHA, the extract concentrations tested resulted in a significant ( p  < 0.01) inhibition of egg hatching in concentration-dependent manner and ranged between 31.86% at 75 μg.mL − 1  to 54.92% at 2400 μg.mL − 1  after a 48 h post-exposure with eggs. For the LMI assays, the aqueous extract of  M. senegalensis  showed a significant ( p  < 0.05) inhibition of larval migration in a concentration-dependent manner. The highest concentration used (2400 μg.mL − 1 ) showed a 37.77% inhibition. The use of polyvinyl polypyrrolidone (PVPP) indicated that tannins and flavonoids were partly involved in the effect since the larval migration was inhibited by 15.5%, but other biochemical compounds were also implicated. On AMIA,  M. senegalensis  was associated with a reduced worm motility after a 24 h post exposure compared to phosphate buffered saline as control ( p  < 0.05). By this time 66.66% of the worms ’  were found immotile or dead in the wells containing plant extract at 2400 μg.mL − 1 . The Phytochemical analysis of aqueous extract of  M. senegalensis  by HPLC-ESI-MS n  detected the presence of proanthocyanidins (20%) and flavonoids (> 50%).    Conclusions  These in vitro results suggest the presence of some anthelmintic properties in  M. senegalensis  extract, which is traditionally used by small farmers in west and central Africa. These effects may be due to the flavonoids and proanthocyanidins present in the extract and need to be studied under in vivo conditions.

bmc veterinary research

In vitro effects of aqueous extract from Maytenus senegalensis (Lam.) Exell stem bark on egg hatching, larval migration and adult worms of Haemonchus contortus