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Background    Mycoplasma synoviae  causes infectious synovitis and respiratory diseases in chickens and turkeys and may lead to egg shell apex abnormalities in chickens; hence possesses high economic impact on the poultry industry. Control of the disease consists of eradication, vaccination or medication. The aim of the present study was to determine the in vitro susceptibility to 14 different antibiotics and an antibiotic combination of  M .  synoviae  strains originating from Hungary and other countries of Central and Eastern Europe.    Results  Minimal inhibitory concentration (MIC) values of a total of 41  M .  synoviae  strains were determined by the microbroth dilution method. The strains were collected between 2002 and 2016 and originated from Hungary ( n  = 26), Austria ( n  = 3), the Czech Republic ( n  = 3), Slovenia ( n  = 3), Ukraine ( n  = 3), Russia ( n  = 2) and Serbia ( n  = 1). Tetracyclines (with MIC 50  values of 0.078 μg/ml, ≤0.25 μg/ml and 0.5 μg/ml for doxycycline, oxytetracycline and chlortetracycline, respectively), macrolides (with MIC 50  values of ≤0.25 μg/ml for tylvalosin, tylosin and tilmicosin), pleuromutilins (with MIC 50  values of 0.078 μg/ml and ≤0.039 μg/ml for tiamulin and valnemulin) and the combination of lincomycin and spectinomycin (MIC 50  1 μg/ml (0.333/0.667 μg/ml)) were found to be the most effective antibiotic agents against  M .  synoviae  in vitro. High MIC values were detected in numerous strains for fluoroquinolones (with MIC 50  values of 1.25 μg/ml and 2.5 μg/ml for enrofloxacin and difloxacin), neomycin (MIC 50  32 μg/ml), spectinomycin (MIC 50  2 μg/ml), lincomycin (MIC 50  0.5 μg/ml) and florfenicol (MIC 50  4 μg/ml). Nevertheless, strains with elevated MIC values were detected for most of the applied antibiotics.    Conclusions  In the medical control of  M. synoviae  infections the preliminary in vitro antibiotic susceptibility testing and the careful evaluation of the data are crucial. Based on the in vitro examinations doxycycline, oxytetracycline, tylvalosin, tylosin and pleuromutilins could be recommended for the therapy of  M .  synoviae  infections in the region.    Electronic supplementary material  The online version of this article (10.1186/s12917-017-1266-2) contains supplementary material, which is available to authorized users.

Antibiotic susceptibility profiles of Mycoplasma synoviae strains originating from Central and Eastern Europe