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Background  Canine B-cell lymphoma is deemed an ideal model of human non-Hodgkin’s lymphoma where the lymphomas of both species share similar clinical features and biological behaviors. However there are some differences between tumor features in both species. In the current study, we sought to evaluate the prognostic efficacy of human B-cell lymphoma prognostic gene signatures in canine B-cell lymphoma.    Methods  The corresponding probe sets of 36 human B-cell lymphoma prognostic genes were retrieved from 2 canine B-cell lymphoma microarray datasets (GSE43664 and GSE39365) (76 samples), and prognostic probe sets were thereafter detected using the univariate and multivariate Cox proportional-hazard model and the Kaplan–Meier analysis. The two datasets were employed both as training sets and as external validation sets for each other. Results were confirmed using quantitative real-time PCR (qRT-PCR) analysis.    Results  In the univariate analysis,  CCND1, CCND2, PAX5, CR2, LMO2, HLA-DQA1, P53, CD38, MYC-N, MYBL1 , and  BIRCS5  were associated with longer disease-free survival (DFS), while  CD44, PLAU , and  FN1  were allied to shorter DFS. However, the multivariate Cox proportional-hazard analysis confirmed  CCND1  and  BIRCS5  as prognostic genes for canine B-cell lymphoma. qRT-PCR used for verification of results indicated that expression level of  CCND1  was significantly higher in B-cell lymphoma patients with the long DFS than ones with the short DFS, while expression level of  BIRCS5  wasn’t significantly different between two groups.    Conclusion  Our results confirmed  CCND1  as important gene that can be used as a potential predictor in this tumor type.    Electronic supplementary material  The online version of this article (doi:10.1186/s12917-016-0919-x) contains supplementary material, which is available to authorized users.

Prognostic efficacy of the human B-cell lymphoma prognostic genes in predicting disease-free survival (DFS) in the canine counterpart