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Background  Serum haptoglobin (Hp) and haptoglobin matrix metalloproteinase 9 complexes (Hp-MMP 9) have been identified as biomarkers with diagnostic potential in cattle with conditions resulting in an acute inflammatory response. The purpose of this study was to evaluate potential diagnostic applications of serum Hp and Hp-MMP 9 concentrations in calves with BRD and establish a timeline for their detection in calves experimentally challenged with  Bibersteinia trehalosi  and  Mannheimia haemolytica.  Thirty-five cross bred dairy calves were inoculated via tracheal catheterization with either a PCR confirmed leukotoxin negative  B. trehalosi  isolate, a PCR confirmed leukotoxin positive  B. trehalosi  isolate, a  Mannheimia haemolytica  isolate, a combination of leukotoxin negative  B. trehalosi  and  M. haemolytica , or a negative control. Serum samples were collected throughout the study. Calves were euthanized and necropsy performed on day 10 post inoculation.    Results   M. haemolytica  inoculated calves had increased lung involvement. Serum Hp and Hp- MMP 9 concentrations were elevated compared to the other treatment groups. Increases in serum Hp and Hp-MMP 9 concentrations for the  M. haemolytica  group were significantly different from other study groups on day 7 of the study.  B. trehalosi  inoculated calves did not have increased lung involvement compared to control calves, but the leukotoxin positive  B. trehalosi  group demonstrated increased serum Hp-MMP 9 concentrations from day 3 to the end of the study compared to the pre-inoculation concentrations.    Conclusion  Serum Hp-MMP 9 concentration is a useful diagnostic tool for detecting early pulmonary inflammation in calves challenged with  B. trehalosi  and  M. haemolytica . Serum Hp-MMP 9 may also be a useful tool in detecting subclinical pulmonary inflammation in challenged calves.

bmc veterinary research

Serum concentrations of haptoglobin and haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complexes of bovine calves in a bacterial respiratory challenge model