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Background   Mycoplasma bovis  is a worldwide pathogen, causative agent of pneumonia, mastitis, arthritis, and a variety of other symptoms in cattle. The economic losses due to mycoplasma pneumonia could be reduced by antibiotic treatment. The aim of the present study was to determine the  in vitro  susceptibility of  M. bovis  strains isolated from cattle in Hungary to eleven antibiotics.    Results  Minimal inhibitory concentration (MIC) values of 35  M. bovis  strains collected from different parts of Hungary between 2010 and 2013 were determined by the microbroth dilution method. Strains with high MIC values were found in the case of all applied antibiotics. The most effective antibiotics tested  in vitro  were fluoroquinolones (MIC 90  danofloxacin 0.312 μg/ml, enrofloxacin 0.312 μg/ml, marbofloxacin 0.625 μg/ml). Our results confirm the observations of increasing MIC values to antibiotics commonly used in the therapy of mycoplasma infections, primarily to tetracyclines; tetracycline (MIC 90  16 μg/ml) and oxytetracycline (MIC 90  ≥ 64 μg/ml) and macrolides; tylosin (MIC 90  ≥ 128 μg/ml) and tilmicosin (MIC 90  ≥ 128 μg/ml). The growth of many  M. bovis  strains was not inhibited by gentamicin (MIC 90  8 μg/ml), spectinomycin (MIC 90  ≥ 256 μg/ml), florfenicol (MIC 90  8 μg/ml) or lincomycin (MIC 90  ≥ 64 μg/ml).    Conclusions  Our results emphasize the necessity of periodic testing for antibiotic susceptibility in this geographic region. Based on our  in vitro  examinations, fluoroquinolones could be the most effective drugs for the therapy of  M. bovis  infections in Hungary. However, current antimicrobial use policies have to be taken into account to avoid further antibiotic resistance development and to reserve fluoroquinolones for the treatment of severe infections which have responded poorly to other classes of antimicrobials.

Antibiotic susceptibility profiles of Mycoplasma bovis strains isolated from cattle in Hungary, Central Europe