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Background  Plants are exposed to diverse pathogens and pests, yet most plants are resistant to most plant pathogens. Non-host resistance describes the ability of all members of a plant species to successfully prevent colonization by any given member of a pathogen species. White blister rust caused by  Albugo  species can overcome non-host resistance and enable secondary infection and reproduction of usually non-virulent pathogens, including the potato late blight pathogen  Phytophthora infestans  on  Arabidopsis thaliana . However, the molecular basis of host defense suppression in this complex plant–microbe interaction is unclear. Here, we investigate specific defense mechanisms in Arabidopsis that are suppressed by  Albugo  infection.    Results  Gene expression profiling revealed that two species of  Albugo  upregulate genes associated with tryptophan-derived antimicrobial metabolites in Arabidopsis.  Albugo laibachii- infected tissue has altered levels of these metabolites, with lower indol-3-yl methylglucosinolate and higher camalexin accumulation than uninfected tissue. We investigated the contribution of these  Albugo -imposed phenotypes to suppression of non-host resistance to  P. infestans . Absence of tryptophan-derived antimicrobial compounds enables  P. infestans  colonization of Arabidopsis, although to a lesser extent than  Albugo -infected tissue.  A. laibachii  also suppresses a subset of genes regulated by salicylic acid; however, salicylic acid plays only a minor role in non-host resistance to  P. infestans .    Conclusions    Albugo  sp. alter tryptophan-derived metabolites and suppress elements of the responses to salicylic acid in Arabidopsis.  Albugo  sp. imposed alterations in tryptophan-derived metabolites may play a role in Arabidopsis non-host resistance to  P. infestans . Understanding the basis of non-host resistance to pathogens such as  P. infestans  could assist in development of strategies to elevate food security.    Electronic supplementary material  The online version of this article (doi:10.1186/s12915-017-0360-z) contains supplementary material, which is available to authorized users.

bmc biology

Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana