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Background  In the midst of the COVID-19 pandemic, to palliate to the lockdown and cover academic programs, the faculty of medicine and pharmaceutical sciences (FMPS) of the university of Dschang (UDs) in Cameroon has implemented e-learning using WhatsApp ®.Aim  Describe the opinion of students and lecturers after its implementation of e-learning at the FMPS of UDs.    Methods  We designed a uniform teaching scheme using WhatsApp ®  during the university lockdown. Students and members of the teaching staff of the FMPS of UDs were enrolled after receiving clear information on the study implementation. At the end of the online-teaching period of two and a half months, we surveyed our students and teaching staff. Sociodemographic characteristics and opinions about e-learning were collected using a standard questionnaire.    Results  We enrolled 229 students and 40 lecturers of the FMPS. Students reported a decremented quality of internet connection ( p  < 0.001, p-homogeneity < 0.001) despite an increased expenditure related to internet use. Electronic devices were broadly used before the implementation of mobile learning. The use of course materials was significantly more challenging among students because of the size/format of lecture notes and internet connection/cost (all  p  < 0.05). Perception of discipline compared to classroom-based lessons was not significantly different among students compared to lecturers (all  p  > 0.05). While lecturers were mainly more comfortable conveying the contents of their lectures, students tended to be less prone to actively participate. The motivation and satisfaction of the latter group toward e-learning were modest compared to classroom-based lectures while their feedback about the organization was positive.    Conclusions  E-learning using WhatsApp ®  could be an effective alternative to conventional classroom-based lessons in the context of COVID-19 pandemic. The use of a blended-learning program including classroom-based sessions could help improve its limitations.    Supplementary Information  The online version contains supplementary material available at 10.1186/s12909-021-02953-9.

Use of WhatsApp®, for distance teaching during COVID-19 pandemic: Experience and perception from a sub-Saharan African setting