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Background    Mucuna pruriens  (L.) has been used for the treatment of several ailments in folkloric medicine. The present study therefore investigates the hepatoprotective and nephroprotective potentials of its leaves extract with a view to providing a potent alternative in the management of liver and kidney diseases.    Methodology  Forty male albino rats were randomly placed into eight groups comprising five animals each. Animals in group I were administered with the distilled water, while groups II and VI were exposed to CCl 4  and rifampicin respectively. Animals in groups III and IV were initially exposed CCl 4  and treated with 50 and 100 mg/kg bw  M. pruriens  respectively. Similarly, groups VII and VIII animals were exposed to rifampicin and treated with 50 and 100 mg/kg bw  M. pruriens  respectively. Animals in group V were treated with 100 mg/kg bw silymarin by oral gavage after an initial exposure to CCl 4 . Selected biomarkers of liver and kidney damage were determined in the serum and organs homogenate. Liver and kidney slices of experimental animals were also stained for histopathological examination.    Results  Exposure to CCl 4  and rifampicin respectively resulted in marked distortion in lipid profile, inhibition of antioxidant enzymes and a surge in ALT, AST, ALP, urea, uric acid, bilirubin and creatine kinase. Treatment with  M. pruriens  extract reversed all deranged biochemical and histopathological parameters in a dose-dependent manner.    Conclusion  Extract of  M. pruriens  leaves restored deranged biochemical and histopathological parameters in the liver and kidney with similar potency to silymarin. Hence, leaf extract of  M. pruriens  is a potential hepatoprotective and nephroprotective agent that can be exploited in the management of liver and kidney diseases.

bmc complementary medicine and therapies

Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat