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Background  Patients with lymphoedema are at high risk of getting bacterial and fungal wound infections leading to acute inflammatory episodes associated with cellulitis and erysipelas. In Ethiopia, wound infections are traditionally treated with medicinal plants.    Methods  Agar well diffusion and colorimetric microdilution methods were used to determine the antibacterial activity of methanol extracts of the three medicinal plants against  Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Shewanella alage , methicillin-resistant  S. aureus  ATCC®43300TM,  Staphylococcus aureus  ATCC25923,  Escherichia coli  ATCC25922,  Klebsiella pneumoniae  ATCC700603, and  Pseudomonas aeruginosa  ATCC37853.    Results  The methanol extract of  L. inermis  leaves showed high activity against all tested bacterial species, which was comparable to the standard drugs. Similarly, the extracts of  A. indica  showed activity against all tested species though at higher concentrations, and higher activity was recorded against  Streptococcus pyogenes  isolates at all concentrations. However, the extract of  A. aspera  showed the lowest activity against all tested species except  Streptococcus pyogenes  isolates. The lowest minimum inhibitory concentration (MIC) was recorded with the extract of  L. inermis  against  E. coli  isolate and  S. aureus  ATCC 25923.    Conclusion  Methanol extracts of  L. inermis, A. indica , and  A. aspera  leaves exhibited antimicrobial activity against selected bacterial isolates involved in wound infections, of which the methanol extracts of  L. inermis  exhibited the highest activity. The results of the present study support the traditional use of plants against microbial infections, which could potentially be exploited for the treatment of wound infections associated with lymphoedema.

bmc complementary medicine and therapies

Antibacterial activity of methanol extracts of the leaves of three medicinal plants against selected bacteria isolated from wounds of lymphoedema patients