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Background  Depression has rapidly progressed worldwide, and the need for an efficient treatment with low side effect has risen.  Melissa officinalis  L and  Lavandula angustifolia  Mill have been traditionally used in Asia for the treatment of depression. Many textbooks of traditional Persian medicine refer to these herbs for the treatment of depression while there are no adequate clinical trials to support this claim.  The present study aimed to evaluate the efficacy of  M. officinalis  and  L. angustifolia  compared to fluoxetine for the treatment of mild to moderate depression in an 8-week randomized, double-blind clinical trial.    Methods  Forty-five adult outpatients who met the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) for major depression, were randomly assigned to 3 groups to daily receive either  M. officinalis  (2 g) or  L. angustifolia  (2 g) or fluoxetine (20 mg) and were assessed in weeks 0, 2, 4 and 8 by the Hamilton Rating Scale for Depression (HAM-D) including 17 items.    Results  Our study showed that  M. officinalis  and  L. angustifolia  effect similar to fluoxetine in mild to moderate depression. (F = 0.131, df = 2,42,  p  = 0.877).    Conclusion  Due to some restrictions in this study including absence of placebo group, large-scale trials are needed to investigate the anti-depressant effect of these two herbs with more details.    Trial registration   IRCT2014061718126N1 . Registration date: 2015-06-04-“Retrospectively registered”.

bmc complementary medicine and therapies

A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression