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Background   Acinetobacter baumannii  is an opportunistic pathogen that causes nosocomial infections especially in patients in intensive care units (ICUs). Accordingly, the aim of our study was to detection  of adeABC  efllux pump encoding genes and antimicrobial effect of the essential oil of  Mentha longifolia  and  Menthol  on the minimum inhibitory concentration (MIC) of imipenem and ciprofloxacin in clinical isolates of  A. baumannii.Methods  A total of 75 clinical isolates of  A. baumannii  were collected. The presence of efflux pump genes was detected by polymerase chain reaction (PCR). The minimum inhibitory concentration (MIC) of the essential oil of  Mentha longifolia  and Menthol and their combined effect with antibiotics were measured by microbroth dilution method and fractional inhibitory concentration (FIC) index.    Results  The frequency of  adeA ,  adeB , and  adeC  genes in clinical isolates of  A. baumannii  were 86.7, 90.7, and 92%, respectively. When the essential oil of  Mentha longifolia  was combined with ciprofloxacin and imipenem, MICs decreased 4- and 8-fold, respectively. In the combination of menthol with imipenem, the resistance to imipenem was reduced from 0- to 16-fold in 90% (63/70) of the isolates.    Conclusion  The presence of efflux pump genes in more than 90% of  A. baumannii  isolates indicates its potential role in inducing imipenem- and ciprofloxacin-resistance in this bacterium. Menthol has an antimicrobial effect as an active ingredient in  Mentha longifolia . In the future, the combination of medicinal plants with antibiotics can be used as a complement in treating diseases caused by drug-resistant bacteria such as  A. baumannii  infections.

bmc complementary medicine and therapies

Detection of adeABC efllux pump encoding genes and antimicrobial effect of Mentha longifolia and Menthol on MICs of imipenem and ciprofloxacin in clinical isolates of Acinetobacter baumannii