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Background  Ocimum species (Lamiaceae) has been traditionally used for treatment of upper respiratory tract infections, bronchitis, coughs, sore throat, and wound healing. The Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of  Ocimum basilicum  ( O. basilicum ) leaves was examined in ovalbumin sensitized animals.    Methods  Wistar rats were divided to six groups; non-sensitized, sensitized to ovalbumin, sensitized and treated with dexamethasone (1.25 μg/mL), and  O. basilicum  extract (0.75, 1.50 and 3.00 mg/mL) in drinking water for 21 days. The levels of interleukin 4 (IL-4), interferon gamma (IFN-γ), IFN-γ/IL-4 ratio, immunoglobulin E (IgE), phospholipase A 2  (PLA 2 ) and total protein (TP) in BALF, and lung pathological changes were examined.    Results  A significant increase in IL-4, IgE, PLA 2  and TP levels, all lung pathological indices as well as significant decrease in IFN-γ/IL-4 ratio was seen in the asthmatic compared to the control rats ( P  < 0.05 to  P  < 0.001). Treatment with  O. basilicum  extract resulted in decreased IL-4, IgE, PLA 2  and TP levels, but increased IFN-γ/IL-4 ratio compared to untreated sensitized rats ( P  < 0.01 to  P  < 0.001). The plant significantly improved the pathological changes of sensitized rats ( P  < 0.05 to  P  < 0.01). The improvement effects of higher concentrations of the  O. basilicum  extract were significantly more than those of dexamethasone ( P  < 0.05 to  P  < 0.001).    Conclusion  The improvement effects of  O. basilicum  on pathological changes, immunological and inflammatory markers in sensitized rats comparable or even more potent than dexamethasone suggests the therapeutic potential of the plant in asthma.

bmc complementary and alternative medicine

Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum leaves and its effect on lung pathological changes in an ovalbumin-induced rat model of asthma