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Background  The present study was aimed to evaluate the molecular level anticaries effect of different medicinal plants against  Streptococcus mutans  ( S.mutans)  glucosyltransferases (gtf).    Methods  A total of six natural sources named as  Terminalia chebula (T.chebula), Psidium guajava (P.guajava), Azadirachta indica (A.indica) and Pongamia pinnata (P.pinnata) ; two essential oils, clove ( Syzygium aromaticum ) and peppermint oil ( Mentha piperita ) were selected as test samples. Hydroalcoholic plant extracts and essential oils were examined for their inhibitory potential on  gtf  isolated from  S.mutans.  Polyherbal mouth wash was prepared and its effect on  gtf  activity was compared with commercial chlorhexidine mouth wash (5%w/v). Enzyme kinetic study was carried out in order to explore the molecular mechanism of enzyme action.    Results  Out of six natural sources tested,  A.indica  has shown maximum inhibitory effect of 91.647% on  gtf  and  T.chebula  has shown IC 50  of 1.091 mg/ml which is significant when compared to standard chlorhexidine. From the final result of kinetic analysis it was found that  T.chebula, P.guajava  and  P.pinnata  have show uncompetitive inhibition where as  A.indica has shown non-competitive inhibition.  Surprisingly, both essential oils have shown allosteric inhibition (sigmoidal response). The polyherbal moutwash has shown significant inhibitory potential on  gtf  (95.936%) when compared to commercial chlorhexidine mouthwash ( p  < 0.05).    Conclusion  All the tested samples have shown considerable  gtf  inhibitory action. Moreover polyherbal mouth wash has shown promising noncompetitive inhibitory activity against  gtf  and it could be the future formulation to combat dental caries.

Design and study of anticaries effect of different medicinal plants against S.mutans glucosyltransferase