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Background  Different plant parts of  Roylea cinerea  (D. Don) Baill. (Lamiaceae),  Clematis grata  Wall. (Ranunculaceae),  Cornus capitata  Wall. (Cornaceae) are traditionally used in the management of diabetes and various other diseases.    Method  The air-dried plant parts from different plants were coarsely powdered and macerated in methanol to obtain their crude extracts. The crude extracts were evaluated for their α-glucosidase inhibitory activity. On the basis of results obtained, the methanolic crude extract of  Cornus capitata  Wall. was further sequentially fractionated in hexane, diethyl ether, ethyl acetate, n-butanol. Fractions obtained were also evaluated for their α-glucosidase inhibitory potential. The kinetic study was performed using Lineweaver Burk plot to evaluate the type of inhibition. Furthermore, in silico analysis was also carried with active sites of the enzyme (PDB ID: 3WY1) using Autodock4.    Results  Among all the plant extracts,  Cornus capitata  extract showed maximum inhibitory activity. Therefore its methanolic extract was further fractionated with the help of different solvents and the maximum activity was shown by the ethyl acetate fraction (IC 50  50 μg/mL). Kinetic analysis indicated that Vmax and Km were increased indicating a competitive type of inhibition. In docking studies, among different constituents known in this plant, betulinic acid showed minimum binding energy (− 10.21 kcal/mol). The kinetic and docking studies have strengthened the observation made in the present study regarding the α-glucosidase inhibitory activity of  Cornus capitata .    Conclusion  The study provided partial evidence for pharmacological basis regarding clinical applications of  Cornus capitata  in the treatment of diabetes suggesting it to be a suitable candidate for the treatment of postprandial hyperglycemia.    Electronic supplementary material  The online version of this article (10.1186/s12906-019-2482-z) contains supplementary material, which is available to authorized users.

In vitro evaluation of the α-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants