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Background  There are increasing interests in natural compounds for cancer chemoprevention. Blocking agents represent an important class of chemopreventive compounds. They prevent carcinogens from undergoing metabolic activation and thereby suppressing their interaction with cellular macromolecular targets.    Methods  The effect of phenolic compounds isolated from  Barleria cristata  var. alba as chemopreventive agent was evaluated. The ethyl acetate fraction of  B. cristata  was subjected to different chromatographic techniques for isolation of its major phenolic compounds. The isolated compounds were evaluated for their potential to induce the cancer chemopreventive enzyme marker NAD(P)H quinonereductase 1 (NQO1) in murine Hepa-1c1c7 cell model.    Results  The ethyl acetate fraction of  B. cristata  var. alba yielded five known compounds identified as verbascoside ( 1),  isoverbascoside ( 2),  dimethoxyverbascoside ( 3) ,  p -hydroxy benzoic acid ( 4) , and apigenin-7-O-glucoside ( 5).  Among the tested compounds, isoverbascoside ( 2 ) was shown to potently induce the activity of the enzyme in a dose –dependent manner. As a functional assay for detoxification, compound  2  was the strongest to protect Hepa-1c1c7 against the toxicity of menadione, a quinone substrate for NQO1.    Conclusion  This effect seemed to be attributed to the compound’s potential to induce both the catalytic activity and protein expression of NQO1 as revealed by enzyme assay and Western blotting, respectively.    Electronic supplementary material  The online version of this article (10.1186/s12906-018-2214-9) contains supplementary material, which is available to authorized users.

bmc complementary and alternative medicine

Phenolics from Barleria cristata var. Alba as carcinogenesis blockers against menadione cytotoxicity through induction and protection of quinone reductase