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Background   Alpinia galanga  (L.) Willd .  commonly called as  Rasna ,  Greater galangal  or  Kulinjan  is a medicinally important rhizome used in Indian traditional system of medicine to cure a number of ailments.  A. galanga  is the main source of a galangin -a medicinally important flavanol which has a number of pharmacological properties viz. anti-mutagenic, and anti-inflammatory. Due to the high demand for the rhizome of  A. galanga  traders are now substituting it with rhizomes of  A. calcarata  and  A. officinarum.Methods  The present study aims to develop high performance thin layer chromatographic (HPTLC) fingerprinting of  A. galanga  with its adulterants or substitutes and to quantify bioactive galangin present thereof. Methanolic extracts were obtained from rhizomes of the three species of  Alpinia  used for HPTLC analysis using silica gel 60 F254 plates and hexane: ethyl acetate: acetic acid (6.2: 2.8: 1.0  v / v / v ); the densitometric analysis was performed at 272 nm.    Results  By comparison of R f  values and of the spectra of the bands with those of the standard galangin was identified in all three samples. HPTLC quantitative analysis of the methanolic extracts showed the decline trend in the quantity of the galangin in the three species of  Alpinia  as  A. galanga  (7.67 ± 0.36 mg/g) >  A. officinarum  (5.77 ± 0.71 mg/g) >  A. calcarata  (4.31 ± 0.44 mg/g). The HPTLC method was validated using International Conference on Harmonization (ICH) guidelines. The HPTLC method showed good linearity, recovery and high precision of biomarker.    Conclusions  Rapid and reproducible method is useful for routine analysis of galangin and quality control of  Alpinia galangal  along with its adulterants or substitutes.

Development and validation of HPTLC fingerprints of three species of Alpinia with biomarker Galangin