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Background  YY-312 is a herbal extract powder from  Imperata cylindrica  Beauvois,  Citrus unshiu  Markovich, and  Evodia officinalis  Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate the efficacy and safety of YY-312 for body fat reduction in overweight adults.    Methods  This was a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial performed in overweight Korean adults aged 19–60 years with a body mass index of 25.0–29.9 kg/m 2 . The daily dose of YY-312 was 2400 mg (containing 1800 mg of active herbal extract and 600 mg of cyclodextrin). Primary outcomes were reductions in body fat mass (BFM) and body fat percentage (BF%) after 12 weeks. Secondary outcomes included reductions in body weight and waist circumference (WC) after 12 weeks.    Results  After 12 weeks, BFM (1.6 kg vs. 0.1 kg;  P  = 0.023) and BF% (1.5% vs. -0.2%;  P  = 0.018) decreased significantly more in the YY-312 group than in the placebo group, as did body weight (2.7 kg vs. 1.0 kg;  P  = 0.014) and WC (2.2 cm vs. 0.8 cm;  P  = 0.049). All safety parameters were within normal limits; no serious adverse events occurred in either group.    Conclusions  In a 12-week clinical trial in overweight adults, YY-312 resulted in significantly greater reduction in body fat vs. placebo, while being safe and well tolerated.    Trial registration  cris.nih.go.kr: ( KCT0001225 ).

bmc complementary and alternative medicine

Effect of a herbal extract powder (YY-312) from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode on body fat mass in overweight adults: a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial