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Background  Emerging drug resistance and hindrance of treatment is provoking scientists to search new, less expensive medicinally active compounds. Dental diseases caused by oral pathogens are very frequent chronic infections around the world. The medical potentials of a lot of Pakistani local herbs and herbal combinations is relatively unknown, hence attempted to explore. A study was designed to investigate potential role of local medicinal herbs for example  Miswak, Kalonji  &  Aloe vera  as antimicrobial, antioxidant and anti-proliferative agents against oral pathogens and cancer cell line.    Methods  Medicinal extracts were prepared in solvents of different polarities. Their antimicrobial activity was determined alone and in combination against oral pathogens. Antioxidant activity was evaluated through Catalase and Superoxide dismutase assay and anti-proliferative activity was evaluated through 3-(4, 5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide) assay.    Results  Plant extracts alone and in combinations were found significantly effective as antimicrobial agent against standard ATCC strains of  C. albicans  and  S. aureus (P  ˂0.001 ) . Especially  Miwak  extract was found highly significant against fungus. Extracts of  Kalonji  were found significant in inhibiting growth of  HeLa  cell lines.  Miswak  and  Kalonji  showed significant levels of antioxidant activity.    Conclusion  Medicinal herbs  Miswak  and  Kalonji  have potential to be used for therapeutic purposes. Results suggested that herbal medicinal composition can be prepared using these extracts after applying scientific standardization methods.

bmc complementary and alternative medicine

Detection of antibacterial activities of Miswak, Kalonji and Aloe vera against oral pathogens &amp; anti-proliferative activity against cancer cell line