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Background  Gurigumu-7 is an important traditional Mongolian medicine frequently used for liver diseases. However, the pharmacological effects and the bioactive constituents are not well understood.    Method  This research was to use CCl 4 -induced liver damage in mice to investigate the hepatoprotective effects of Gurigumu-7 and the methanol eluted fraction from a DIAION column of an extract of Gurigumu-7 (MF). The chemical constituents of MF were analyzed by UPLC-MS.    Results  Pretreated orally with MF (66, 132 and 264 mg/kg) once a day for 4 days dose-dependently suppressed CCl 4 -induced mice liver histopathological changes and serum aminotransferase activities (alanine transaminase: 1144.0 ± 787.2  v.s . 2461.8 ± 1072.7 U/L,  p  < 0.05; aspartate transaminase: 1173 ± 785.3  v.s.  2506.6 ± 1140.7 U/L,  p  < 0.01). MF treated group demonstrated increased levels of SOD (108.19 ± 30.32  v.s.  75.75 ± 5.37 U/mg protein,  p  < 0.01) but decreased levels of malonyldialdehyde (7.68 ± 1.95  v.s.  44.32 ± 16.68 nmol/mg protein,  p  < 0.01) compared to the CCl 4  control group. More than 30 chemical constituents were quantified, and MF was found to be rich in ellagic acid (297.97 mg/g), luteolin and its glucosides (35.10 mg/g), apigenin and its glucosides (>30 mg/g), ursolic acid (14.91 mg/g), bidenoside C (8.75 mg/g), and proanthocyanidins (15.64 mg/g in proanthocyanidin A2 equivalent).    Conclusion  The methanol eluted fraction (MF) from a DIAION column of an extract of the Mongolian medicine-Gurigumu-7 was found to be more hepatoprotective than Gurigumu-7. The results suggested that MF is a promising bioactive fraction for the development of new hepatoprotective medicine with better formulation and quality control properties.

Hepato-protective effects and chemical constituents of a bioactive fraction of the traditional compound medicine-Gurigumu-7