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Background  Natural products display numerous therapeutic properties (e.g., antibacterial activity), providing the population with countless benefits. Therefore, the search for novel biologically active, naturally occurring compounds is extremely important. The present paper describes the antibacterial action of the  Copaifera langsdorffii  oleoresin and ten compounds isolated from this oleoresin against multiresistant bacteria; it also reports the antiproliferative activity of the  Copaifera langsdorffii  oleoresin and (-)-copalic acid.    Methods  MICs and MBCs were used to determine the antibacterial activity. Time-kill curve assays provided the time that was necessary for the bacteria to die. The Minimum Inhbitory Concentration of Biofilm (CIMB 50 ) of the compounds that displayed the best results was calculated. Cytotoxicity was measured by using the XTT assay.    Results  The diterpene (-)-copalic acid was the most active antibacterial and afforded promising Minimum Inhibitory Concentration (MIC) values for most of the tested strains. Determination of the bactericidal kinetics against some bacteria revealed that the bactericidal effect emerged within six hours of incubation for  Streptococcus pneumoniae . Concerning the antibiofilm action of this diterpene, its MICB 50  was twofold larger than its CBM against  S. capitis  and  S. pneumoniae . The XTT assay helped to evaluate the cytotoxic effect; results are expressed as IC 50 . The most pronounced antiproliferative effect arose in tumor cell lines treated with (-)-copalic acid; the lowest IC 50  value was found for the human glioblastoma cell line.    Conclusions  The diterpene (-)-copalic acid is a potential lead for the development of new selective antimicrobial agents to treat infections caused by Gram-positive multiresistant microorganisms, in both the sessile and planktonic mode. This diterpene is also a good candidate to develop anticancer drugs.

Copaifera langsdorffii oleoresin and its isolated compounds: antibacterial effect and antiproliferative activity in cancer cell lines