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Background   Antrodia camphorata  is a geographically special fungus and is one of the precious traditional medicines of Taiwan. A lot of reports have addressed its antioxidant activities and anticancer activities. In order to understand whether these protection effects were resulted from its ability of preventing DNA against hydroxyl radical damage, the  A. camphorata  extract was used to examine its antioxidant, antimutagenic and DNA-protective activities.    Methods   A. camphorata  extract was prepared by extracting the lyophilized powder of  A. camphorata  mycelium with distilled water. The antioxidative activity of this  A. camphorata  extract was then evaluated by 2,2-diphenyl-1-picrylhydrozyl (DPPH) radical-scavenging assay, and the antimutagenic activities of the extract against direct mutagen 4-nitroquinoline N-oxide (4NQNO) and indirect mutagen benzo[a]pyrene (B[a]P) were evaluated by Ames test. The effects of the  A. camphorata  extract in terms of DNA protection against hydroxyl radical damage were also investigated.    Results  It was found that the higher the concentration of  A. camphorata  extracts, the higher the DPPH radical-scavenging effect.  A. camphorata  extract at concentrations between 0.625 and 10 mg/ml was found to be neither toxic nor mutagenic. However, the higher  A. camphorata  concentration (10 mg/ml) used in the test showed higher inhibitory effects on 4NQNO in a dose-dependent manner. The  A. camphorata  extract also showed reducing and scavenging activities against superoxide anion radical and also exhibited protective effects on DNA against hydroxyl radical-induced damage.    Conclusions  Results suggested that  A. camphorata  is a non-toxic and novel material with antioxidant, antimutagenic and DNA-protective activities and could be developed into health foods.

Effects of Antrodia camphorata extracts on anti-oxidation, anti-mutagenesis and protection of DNA against hydroxyl radical damage