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Background  Hypha essential genes ( HEGs ) of  Candida Albicans  have been emerging into scholar’s attention, little known about their functions in oral lichen planus (OLP) with an uncovered etiology. This research aimed to observe necessary genes in biphasic  C. albicans  from OLP and study their relevance in pathogenesis, so as to evaluate possible roles of morphologic switching in etiology of OLP.    Methods  Samples were collected from OLP lesions of patients, mycelia were cultured and total RNA was extracted then subjected to reverse transcription-PCR and real-time PCR.    Results   HWP1  and  HGC1  were significantly expressed in hyphae phase and weakly detected in yeast phase, while there was no significant difference of  EFG1, ALS3, and ECE1  between in yeast and mycelia.    Conclusion   HGC1  and  HWP1  were confirmed to be hypha essential genes, with HGC1 for hypha morphogenesis and  HWP1  for adhesion invasion in pathogenesis of  C. albicans  in OLP.  ALS3, ECE1  and  EFG1  played minor roles in hyphae maintenance and adhesion for hyphae. These might be deemed as hints for the etiology of OLP and indicate  HGC1  and  HWP1  to be a priority of potential drug target.

Hypha essential genes in Candida albicans pathogenesis of oral lichen planus: an in-vitro study