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Background  Saliva plays a significant role in maintaining oral health and oral bacterial milieu. Difference in oxidative stress (OS) levels in saliva in conjunction with bacterial load between pregnant and non-pregnant women has not been studied previously. We hypothesized that the physiological changes in pregnancy alter oral bacterial milieu by promoting growth of  Streptococcus mutans  (SM) and  Lactobacillus  (LB), and increase OS in saliva. The aim of this study was to measure and compare the oral bacterial milieu, OS and total anti-oxidative capacity (TAC) in the saliva of pregnant and non-pregnant women.    Method  In this cross-sectional study, we assessed oral bacterial milieu by culturing the SM and LB by using commercial kits, TAC by measuring 2, 2′-Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic Acid (ABTS) free radical scavenging activity spectrophotometrically and OS levels by measuring malondialdehyde (MDA) levels with commercial kits in the saliva of pregnant women ( n  = 38) at 18–20 weeks of gestation, who were compared with age-matching healthy non-pregnant women ( n  = 50).    Results   Streptococcus mutans  were found to be more abundant in the saliva of pregnant women compared with non-pregnant women ( p  = 0.003) but the difference was not significant for the LB ( p  = 0.267). TAC was found to be 46% lower in pregnant women’s saliva compared to non-pregnant women [optical density (OD) measured at 731 nm as 0.118 ± 0.01 vs. 0.063 ± 0.02;  p  < 0.001]. OS, expressed as saliva MDA levels, was found to be 16% higher in pregnant women compared to non-pregnant women (1.07 nM MDA vs. 0.92 nM MDA;  p  = 0.023).    Conclusion  Pregnancy has an adverse impact on oral bacterial milieu as demonstrated by increased colonization with  Streptococcus mutans  together with higher OS levels and decreased TAC levels in saliva. This emphasizes the importance of improved oral hygiene and provision of oral healthcare services during pregnancy care.

Oxidative stress levels and oral bacterial milieu in the saliva from pregnant vs. non-pregnant women