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Background  The extent to which the composition and diversity of the oral microbiome varies with age is not clearly understood.    Methods  The 16S rRNA gene of subgingival plaque in 1219 women, aged 53–81 years, was sequenced and its taxonomy annotated against the Human Oral Microbiome Database (v.14.5). Composition of the subgingival microbiome was described in terms of centered log(2)-ratio (CLR) transformed OTU values, relative abundance, and prevalence. Correlations between microbiota abundance and age were evelauted using Pearson Product Moment correlations.  P -values were corrected for multiple testing using the Bonferroni method.    Results  Of the 267 species identified overall,  Veillonella dispar  was the most abundant bacteria when described by CLR OTU (mean 8.3) or relative abundance (mean 8.9%); whereas  Streptococcus oralis, Veillonella dispar and Veillonella parvula  were most prevalent (100%, all) when described as being present at any amount. Linear correlations between age and several CLR OTUs (Pearson  r  = − 0.18 to 0.18), of which 82 (31%) achieved statistical significance ( P  < 0.05). The correlations lost significance following Bonferroni correction. Twelve species that differed across age groups (each corrected  P  < 0.05); 5 (42%) were higher in women ages 50–59 compared to ≥70 (corrected  P  < 0.05), and 7 (48%) were higher in women 70 years and older.    Conclusions  We identified associations between several bacterial species and age across the age range of postmenopausal women studied. Understanding the functions of these bacteria could identify intervention targets to enhance oral health in later life.

Composition and diversity of the subgingival microbiome and its relationship with age in postmenopausal women: an epidemiologic investigation