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Background  Mixed dentition space analysis methods using regression equations, namely, Moyers’ analysis and Tanaka-Johnston analysis are commonly used around the world. However, the applicability of these analyses among different racial groups have been questioned. The primary objective of this study was to assess the applicability of the Moyers’ and Tanaka-Johnston analyses among Nepalese Mongoloids and to develop regression equations for the same population if needed.    Methods  One hundred (50 males and 50 females) pre-treatment study models of the Nepalese Mongoloid patients undergoing orthodontic treatment were retrieved from the archives of the department of Orthodontics. The mesiodistal widths of mandibular incisors and widths of canines and premolars of all 4 quadrants were measured by a single investigator using a digital caliper to the nearest 0.01 mm. Predicted widths of canines and premolars were obtained using standard Moyers’ and Tanaka-Johnston analyses and then compared with the measured widths.    Results  The measured widths of canines and premolars were significantly different from the predicted widths obtained from Moyers’ and Tanaka-Johnston analyses. Strong and positive correlations were found between the sum of mesiodistal widths of mandibular incisors and the sum of mesiodistal widths of canines and premolars in males (0.73 for maxillary arch and 0.68 for mandibular arch) and females (0.64 for maxillary arch and 0.79 for mandibular arch).    Conclusions  The Moyers’ and Tanaka-Johnston analyses did not accurately predict the mesiodistal width of unerupted canines and premolars for Nepalese Mongoloid population. Hence, new regression equations have been developed for this population. However, validation studies should be conducted to confirm the applicability and accuracy of these equations.    Electronic supplementary material  The online version of this article (10.1186/s12903-018-0677-1) contains supplementary material, which is available to authorized users.

New regression equations for mixed dentition space analysis in Nepalese mongoloids