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Background  The genotypic diversity and cariogenicity of  C. albicans  from the dental plaque of children are poorly understood. This study aimed to explore the genotypic diversity and cariogenicity of  C. albicans  from children with early childhood caries and caries-free children.    Methods  Dental plaque samples from 238 children with early childhood caries and from 125 caries-free children were collected for  C. albicans  isolation. A PCR method based on 25S rDNA was used to analyze  C. albicans  genotypes, and the strains with different genotypes were tested with regard to acidogenicity and aciduricity.    Results  Among 129  C. albicans  isolates, 79 (61.2 %) belonged to genotype A. The distribution frequency of genotypes A and C or genotypes B and C showed no significant difference between children with early childhood caries and caries-free children ( p  = 0.178 and 0.148), whereas genotypes A and B exhibited significantly different distributions ( p  = 0.010). No significant differences in aciduricity were found among the three genotypes, but the acidogenicity of genotypes B and C differed significantly from that of genotype A at pH 4.0.    Conclusions  The genotypic distribution of  C. albicans  is associated with the caries experience of children, and the genotype may be related to its acidogenicity at pH 4.0.

Genotypic diversity and cariogenicity of Candida albicans from children with early childhood caries and caries-free children