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Background  A defective skin barrier and bacterial colonization are two important factors in maintenance and progression of atopic dermatitis and chronic allergic/irritant hand dermatitis. A water-based lipid delivery system containing physiologic lipids was previously shown to be a useful adjunct in the treatment of hand dermatitis. We tested the ability of this formulation to penetrate into the viable epidermis and in addition assessed its antibacterial properties.    Methods  Epidermal penetration of the product was assessed by fluorescence microscopy. Recovery of  Escherichia coli  and  Staphylococcus aureus  MRSA from skin treated with Neosalus® foam was quantified.    Results  Components of Neosalus® penetrated the stratum corneum and were distributed throughout the viable epidermis. Neosalus® significantly decreased recovery of both  Staphylococcus aureus  and  Escherichia coli  from the skin surface.    Conclusions  The ability of components of Neosalus® to be taken up into the viable epidermis and potentially made available for incorporation into the barrier lipids, combined with antibacterial properties, indicate that this formulation may be valuable not only in chronic hand dermatitis, but also in various other forms of dermatitis.    Trial registration  Current Controlled Trials  ISRCTN18191379 , 28/12/2018, retrospectively registered.

Proderm technology: a water- based lipid delivery system for dermatitis that penetrates viable epidermis and has antibacterial effects