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Background  Laparoscopy induces adhesion due to ischemia-reperfusion injury. However, the detail pathomechanism is poorly understood. This study aimed to investigate the impact of laparoscopy on mast cell and mesothelium morphological changes in the rat.    Methods  Forty-nine males of Sprague-Dawley  Rattus norvegicus  were divided into four groups: a) control and b) intervention groups P1, P2, and P3 that underwent 60 min laparoscopic using carbon dioxide (CO 2 ) insufflation at 8, 10, and 12 mmHg groups, respectively. Serum hydrogen peroxide (H 2 O 2 ), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), and oxidative stress index (OSI) levels were determined 24 h after laparoscopy. Histopathological analyses of mast cell infiltration and degranulation and mesothelium thickness in the liver, greater omentum, mesenterium, small intestine, and peritoneum were performed 7 days after the procedure.    Results  H 2 O 2 , MDA, and OSI levels were significantly increased in the intervention groups compared with the control ( p <0.05), while the SOD and CAT levels were decreased in the intervention groups compared with the control ( p <0.05). Mast cell infiltration and degranulation were higher in the intervention groups than in control ( p <0.05), while the mesothelium thickness was significantly lower in the laparoscopic groups than in control ( p <0.05). Interestingly, the decrease in mesothelium thickness was strongly associated with the increase in mast cell infiltration and degranulation ( p <0.01).    Conclusions  Our study shows that laparoscopy in rats increases mast cell infiltration and degranulation, which also results in and correlates with a decrease in mesothelial thickness.

The effect of laparoscopy on mast cell degranulation and mesothelium thickness in rats