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Background  The existence of latent low-virulence anaerobic bacteria in degenerated intervertebral discs (IVDs) remains controversial. In this study, the prevalence of low-virulence anaerobic bacteria in degenerated IVDs was examined, and the correlation between bacterial infection and clinical symptoms was analysed.    Methods  Eighty patients with disc herniation who underwent discectomy were included in this study. Under a stringent protocol to ensure sterile conditions, 80 disc samples were intraoperatively retrieved and subjected to microbiological culture. Meanwhile, tissue samples from the surrounding muscle and ligaments were harvested and cultured as contamination markers. The severity of IVD degeneration and the prevalence of Modic changes (MCs) were assessed according to preoperative MRI analysis.    Results  Of the 80 cultured discs, 54 were sterile, and 26 showed the presence of bacteria:  Propionibacterium acnes  (21 cases) and coagulase-negative  staphylococci  (5 cases). MRI revealed that the presence of bacteria was significantly associated with MCs ( P <0.001). However, there was no significant association between bacterial infection and the severity of IVD degeneration ( P  = 0.162).    Conclusions  Our findings further validated the presence of low-virulence anaerobic bacteria in degenerated IVDs, and  P. acnes  was the most frequent bacterium. In addition, the latent infection of bacteria in IVDs was associated with Modic changes. Therefore, low-virulence anaerobic bacteria may play a crucial role in the pathophysiology of MCs and lumbar disc herniation.

Latent infection of low-virulence anaerobic bacteria in degenerated lumbar intervertebral discs