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Objective  Chronic obstructive pulmonary disease (COPD) is a complicated multi-factor, multi-gene disease. Here, we aimed to assess the association of genetic polymorphisms in  LINC01414/ LINC00824  and interactions with COPD susceptibility.    Methods  Three single nucleotide polymorphisms (SNPs) in  LINC01414/LINC00824  was genotyped by Agena MassARRAY platform among 315 COPD patients and 314 controls. Logistic analysis adjusted by age and gender were applied to estimate the genetic contribution of selected SNPs to COPD susceptibility.    Results   LINC01414  rs699467 (OR = 0.73, 95% CI 0.56–0.94,  p  = 0.015) and  LINC00824  rs7815944 (OR = 0.56, 95% CI 0.31–0.99,  p  = 0.046) might be protective factors for COPD occurrence, while  LINC01414  rs298207 (OR = 2.88, 95% CI 1.31–6.31,  p  = 0.008) risk-allele was related to the increased risk of COPD in the whole population. Rs7815944 was associated with the reduced risk of COPD in the subjects aged > 70 years (OR = 0.29,  p  = 0.005). Rs6994670 (OR = 0.57,  p  = 0.007) contribute to a reduced COPD risk, while rs298207 (OR = 7.94,  p  = 0.009) was related to a higher susceptibility to COPD at age ≤ 70 years. Rs298207 (OR = 2.54,  p  = 0.043) and rs7815944 (OR = 0.43,  p  = 0.028) variants was associated COPD risk among males. Rs7815944 (OR = 0.16,  p  = 0.031) was related to the reduced susceptibility of COPD in former smokers. Moreover, the association between rs298207 genotype and COPD patients with dyspnea was found (OR = 0.50,  p  = 0.016), and rs7815944 was related to COPD patients with wheezing (OR = 0.22,  p  = 0.008).    Conclusion  Our finding provided further insights into  LINC01414 / LINC00824  polymorphisms at risk of COPD occurrence and accumulated evidence for the genetic susceptibility of COPD.    Supplementary Information  The online version contains supplementary material available at 10.1186/s12890-021-01579-3.

LINC01414/LINC00824 genetic polymorphisms in association with the susceptibility of chronic obstructive pulmonary disease