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Background  The respiratory microbiome is altered in COPD patients but its relationship with core components of the disease, such as the severity of airflow limitation, the frequency of exacerbations or the circulating levels of eosinophils, is unclear.    Methods  Cross-sectional study comprising 72 clinically stable COPD patients (mean age 68 [SD 7.9] years; FEV1 48.7 [SD 20.1]% of reference) who provided spontaneous sputum samples for 16S rRNA gene amplification and sequencing. The microbiome composition was analysed with QIIME.    Results  We observed that: (1) more severe airflow limitation was associated with reduced relative abundance (RA) of  Treponema  and an increase in  Pseudomonas ; (2) patients with ≥2 exacerbations the previous year showed a significantly different bacterial community with respect to non-exacerbators ( p  = 0.014), with changes in 13 genera, including an increase of  Pseudomonas,  and finally, (3) peripheral eosinophils levels ≥2% were associated with more diverse microbiome [Chao1 224.51 (74.88) vs 277.39 (78.92)  p  = 0.006; Shannon 3.94 (1.05) vs 4.54 (1.06)  p  = 0.020], and a significant increase in the RAs of 20 genera.    Conclusion  The respiratory microbiome in clinically stable COPD patients varies significantly according to the severity of airflow limitation, previous history of exacerbations and circulating eosinophils levels.    Electronic supplementary material  The online version of this article (10.1186/s12890-019-0867-x) contains supplementary material, which is available to authorized users.

bmc pulmonary medicine

Relationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients