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Background   Aspergillus fumigatus  is frequently encountered in sputum samples of patients with cystic fibrosis (CF), which traditionally has been interpreted as saprophytic airway colonization. However, this mere bystander role has been challenged by recent data. There is now evidence that  Aspergillus fumigatus  accelerates the decline of pulmonary function.  (1→3)-β-D-glucan (BDG) and galactomannan (GM) are highly sensitive fungal biomarkers that are used to diagnose invasive fungal disease. However, their diagnostic value in CF patients is largely unknown.    Methods  We conducted a retrospective cohort study on 104 CF patients to determine whether serum BDG and GM levels correlate with parameters such as  Aspergillus- positive sputum cultures and lung function.    Results   Aspergillus fumigatus  was persistently detected in 22 of the 104 CF patients (21%). Mean serum BDG and GM levels in the  Aspergillus -positive patients were significantly higher than in those without persistent  Aspergillus  detection (89 versus 40 pg/ml [ p  = 0.022] and 0.30 versus 0.15 ODI [ p  = 0.013], respectively). 27 and 7 patients had elevated BDG (≥ 60 pg/ml) or GM levels (> 0.5 ODI), respectivly. BDG and GM levels showed a significant correlation ( p  = 0.004). Patients with increased serum concentrations of BDG were more frequently  Aspergillus -positive (40.7 versus 14.3%, p = 0.004) and had a significantly lower forced expiratory volume in one second (FEV1) than patients with a normal BDG (61.6 versus 77.1%,  p  = 0.007). In the multivariate analysis, BDG but not GM or the growth of  A. fumigatus , proved to be an independent predictor for the FEV1.    Conclusions  CF patients with persistent  Aspergillus  detection have elevated BDG and GM levels which ranged between healthy and invasively infected patients. Serum BDG may be superior to GM and fungal culture in predicting an impaired lung function in CF patients.

Serum (1→3)-β-D-glucan and galactomannan levels in patients with cystic fibrosis: a retrospective cohort study