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Background  Infection with  Burkholderia cepacia complex  ( Bcc ) results in a heterogeneous clinical course ranging from asymptomatic colonization of the airways to fulminant respiratory failure in patients with cystic fibrosis (CF). Early eradication of  Pseudomonas aeruginosa  improves clinical outcomes. The efficacy and clinical outcomes following implementation of an eradication protocol for  Bcc  are less well understood.    Methods  We developed and implemented a single center  Bcc  eradication protocol that included an intensive combination of intravenous, inhaled, and oral antibiotic therapies based on in vitro sensitivities. We conducted a retrospective cohort analysis of clinical outcomes compared to patients with chronic  Bcc  infection.    Results  Six patients were identified as having a newly acquired  Bcc  colonization and were placed on the eradication protocol. Sequential sputum samples after completion of the protocol demonstrated sustained clearance of  Bcc  in all patients. Lung function and nutritional status remained stable in the year following eradication.    Conclusion  Clearance of  Bcc  from sputum cultures using a standardized protocol was successful at one year and was associated with clinical stability.

Implementation of a successful eradication protocol for Burkholderia Cepacia complex in cystic fibrosis patients