English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  The aim of this study was to assess whether serology and spirometry and the combination of both can complement culture-based detection for earlier recognition of  Pseudomonas aeruginosa  infection in children with cystic fibrosis.    Methods  A 4 year longitudinal prospective study that included 67 Slovenian children with cystic fibrosis with a mean age of 10.5 years was conducted. Serology, spirometry and a scoring system combining serology and spirometry were assessed and compared. Infection was confirmed with isolation of  Pseudomonas aeruginosa  from respiratory samples.    Results  There was a significantly positive correlation between serology and the combination of serology and spirometry and  Pseudomonas aeruginosa  isolation ( P  < 0.01 for both) and a significantly negative correlation between spirometry and  Pseudomonas aeruginosa  isolation ( P  < 0.05). An increase in serology for 1 ELISA unit increased the possibility of  Pseudomonas aeruginosa  isolation 1.6 times. A fall in FEV1% predicted for 10% increased the possibility of  Pseudomonas aeruginosa  isolation 9.8 times. Binary logistic regression analysis was used to determine the odds ratios and 95% confidence intervals for all three approaches. Serology had the highest specificity (0.80) and the combination of serology and spirometry the highest sensitivity (0.90). Both had a high negative predictive value (0.93 and 0.79 respectively).    Conclusion  Using serology and the combination of serology and lung function measurement can be beneficial for earlier detection of infection with  Pseudomonas aeruginosa  in children with cystic fibrosis when done simultaneously with standard culture-based detection from respiratory samples.

bmc pulmonary medicine

Assessment of serology and spirometry and the combination of both to complement microbiological isolation for earlier detection of Pseudomonas aeruginosa infection in children with cystic fibrosis