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The Lives Saved Tool (LiST) is designed to support sound public health decisions for women and children. Simply put, it is a computer-based model that draws on best-available evidence to estimate the effect of public health interventions on nutritional status and the causes of mortality among women and children [1]. Model input data include geography-specific demographic information on population, fertility, nutritional status and patterns of mortality by cause and risk factors, the efficacy and – when available – effectiveness of individual interventions, and estimates of the proportion of individuals who need an intervention who actually receive it (coverage). LiST has evolved continuously since 2003, when the Bellagio Child Survival Study Group used available coverage data to generate estimates of the child deaths that could be prevented through the achievement of high and equitable coverage with known interventions [2]. This first application led to important changes in priorities for women and children at global and national levels [3]. In the 14 intervening years, LiST has changed in important ways, always guided by a commitment to generating and using sound science to improve policies and programs for women and children. The software has been used extensively by national and sub-national programs and by large bilateral and international organizations as part of their planning process for maternal and child health. This supplement – the fourth in an ongoing series [4–6]– makes available the research reports that support these changes and provides the basis for our continuing research and development program in four areas.

Introduction: reporting on updates in the scientific basis for the Lives Saved Tool (LiST)