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Background  A body mass index (BMI) ≥30 kg/m 2  and a waist circumference (WC) ≥80 cm in women (WCF) or ≥90 cm in men (WCM) are reference cardiometabolic risk markers (CMM) for Mexicans adults. However, their reliability to predict other CMM (index tests) in young Mexicans has not been studied in depth.    Methods  A cross-sectional descriptive study evaluating several anthropometric, physiological and biochemical CMM from 295 young Mexicans was performed. Sensitivity (Se), specificity (Sp) and  Youden’s index  ( J ) of reference BMI/WC cutoffs toward other CMM ( n  = 14) were obtained and their most reliable cutoffs were further calculated at  Jmax .    Results  Prevalence, incidence and magnitude of most CMM increased along the BMI range ( p  < 0.01). BMI explained 81 % of WC’s variance [Se (97 %), Sp (71 %),  J  (68 %),  J max (86 %), BMI = 30 kg/m 2 ] and 4–50 % of other CMM. The five most prevalent (≥71 %) CMM in obese subjects were high WC, low HDL-C, and three insulin-related CMM [Fasting insulin, HOMA-IR, and QUICKI]. For a BMI = 30 kg/m 2 ,  J  ranged from 16 % (HDL-C/LDL-C) to 68 % (WC), being moderately reliable ( J max = 61–67) to predict high uric acid (UA), metabolic syndrome (MetS) and the hypertriglyceridemic-waist phenotype (HTGW). Corrected WCM/WCF were moderate-highly reliable ( J max = 66–90) to predict HTGW, MetS, fasting glucose and UA. Most CMM were moderate-highly predicted at 27 ± 3 kg/m 2  (CI 95 %, 25–28), 85 ± 5 cm (CI 95 %, 82–88) and 81 ± 6cm (CI 95 %, 75–87), for BMI, WCM and WCF, respectively.    Conclusion  BMI and WC are good predictors of several CMM in the studied population, although at different cutoffs than current reference values.

Cardiometabolic risk in young adults from northern Mexico: Revisiting body mass index and waist-circumference as predictors