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Background  The number of people with Internet gaming addiction (IGA) is increasing around the world. IGA is known to be associated with personal characteristics, psychosocial factors, and physiological factors. However, few studies have examined the genetic factors related to IGA. This study aimed to investigate the association between IGA and stress-related genetic variants.    Methods  This cross-sectional study was conducted with 230 male high school students in a South Korean city. We selected five stress-related candidate genes:  DAT1, DRD4, NET8, CHRNA4,  and  CRHR1 . The  DAT1  and  DRD4  genes were genotyped by polymerase chain reaction, and the  NET8, CHRNA4,  and  CRHR1  genes were genotyped by pyrosequencing analysis. We performed a Chi-square test to examine the relationship of these five candidate genes to IGA.    Results  Having the AA genotype and the A allele of the  CRHR1  gene (rs28364027) was associated with higher odds of belonging to the IGA participant group ( p  = .016 and  p  = .021, respectively) than to the non-IGA group. By contrast, the  DAT1, DRD4, NET8, and CHRNA4  gene polymorphisms showed no significant difference between the IGA group and control group.    Conclusions  These results indicate that polymorphism of the  CRHR1  gene may play an important role in IGA susceptibility in the Korean adolescent male population. These findings provide a justification and foundation for further investigation of genetic factors related to IGA.

Genetic association of human Corticotropin-Releasing Hormone Receptor 1 (CRHR1) with Internet gaming addiction in Korean male adolescents