English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Biomarkers are now widely used in many fields of medicine, and the identification of biomarkers that predict antipsychotic efficacy and adverse reactions is a growing area of psychiatric research. Monoamine molecules of the peripheral bloodstream are possible prospective biomarkers based on a growing body of evidence indicating that they may reflect specific changes in neurotransmitters in the brain. The aim of this study was to detect peripheral biogenic amine indicators of patients with acute psychosis and to test the correlations between the biological measures studied and the psychopathological status of the patients.    Methods  This research included 60 patients with acute psychosis treated with olanzapine ( n  = 30) or haloperidol ( n  = 30). Here, we measured biogenic amine indicators, including mRNA levels of dopamine receptor D4 ( DRD4 ) and the serotonin 2A receptor ( 5HTR2A ), in peripheral blood mononuclear cells (PBMCs) using quantitative real-time polymerase chain reaction and serum dopamine concentrations by enzyme linked immunosorbent assay (ELISA). Psychopathological status was evaluated using psychometric scales. The assessments were conducted prior to and after 14 and 28 days of treatment.    Results  The administration of haloperidol, but not olanzapine, up-regulated  5HTR2A  mRNA in a linear manner, albeit without statistical significance ( p  = 0.052). Both drugs had non-significant effects on  DRD4  mRNA levels. Nevertheless, a positive correlation was found between  DRD4  and  5HTR2A  mRNA levels over a longitudinal trajectory, suggesting co-expression of the two genes.  A significant positive correlation was observed between  5HTR2A  mRNA levels and total Positive and Negative Syndrome Scale (PANSS) scores in both groups of patients before treatment. A significant correlation between baseline  5HTR2A  mRNA levels and PANSS scores on days 14 and 28 of treatment remained for patients treated with olanzapine only. Moreover, a significant positive correlation was observed between blood serum dopamine levels and scores on extrapyramidal symptom scales in the olanzapine group.    Conclusions  The  DRD4  and  5HTR2A  genes are co-expressed in PBMCs during antipsychotic administration. Despite a correlation between the studied biogenic amine indicators and the psychopathological status of patients, reliable biomarkers of treatment response could not be determined.

Potential diagnostic markers of olanzapine efficiency for acute psychosis: a focus on peripheral biogenic amines