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Background Group A  Streptococcus  has been recognized as an important human pathogen and it remains among the top ten causes of mortality from an infectious disease. Group A  Streptococcus  throat carriage plays an important role in the development of infection and transmission to contacts. In Ethiopia, there is little information about screening of children for group A  Streptococcus  carriage. Objective This study was aimed to assess the magnitude of throat carriage, associated factors, and antimicrobial susceptibility pattern of group A  Streptococcus  among healthy school children in Jigjiga city, Eastern Ethiopia from 12 April to 27 May 2021. Method A cross-sectional study was conducted enrolled by simple random sampling. Data on socio-demographic and related characteristics were gathered using pretested structured questionnaire. The throat sample was collected from 462 healthy school children and immediately transported to Jigjiga University Sultan Sheik Hassan referral hospital laboratory for investigation. Identification of group A  Streptococcus  was done by colony characterstics, gram staining, catalase negativity, bacitracin sensitivity, and Pyrrolidonyl arylamidase tests. Antibiotic susceptibility test was done on Muller-Hinton agar containing 5% sheep blood by modified Kirby-Bauer disc diffusion method. The data were coded, cleaned, and entered onto EpiData Version 3.1 then exported to SPSS version 26.0 for analysis. Bivariate and multivariable logistic regression through adjusted odds ratio (AOR) was used to determine the relationship between culture-positivity rates of GAS and predictor variables. A  p -value &lt; 0.05 was taken as statistically significant on multivariable analysis. Results The overall prevalence of group A  Streptococcus  throat culture rate was 10.6% (95%CI; 8.1%—13.7%). Previous family member who had a sore throat, children living with larger families (more than 11 members), and children living with non-immediate families were significantly associated with culture-positivity rates of GAS. Children who live with a family member with a sore throat compared with those who lived with in a family with no history of sore throat (AOR = 2.51; 95%CI 1.09–5.73), children who live with a large family comared to children living in families with less members (AOR = 4.64; 95% CI 1.53–14.1), and children who live with non-immediate families compared to children living with their mothers (AOR = 3.65; 95% CI 1.39 – 9.61), showed significant association with group A  Streptococcus  carriage rate. Resistance to all other antibiotics tested was low (&lt; 5%). Multidrug resistance was found in 4.1% of isolates. Conclusion The present study showed 10.6% throat carriage of group A  Streptococcus . Family member with a sore throat, having a large family, and living with non-immediate families have all been identified as independent predictors of carriage prevalence.

bmc pediatrics

Throat carriage rate, associated factors, and antimicrobial susceptibility pattern of group A Streptococcus among healthy school children in Jigjiga City, Eastern Ethiopia