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Background  The Pediatric Quality of Life Inventory (PedsQL) is a modular instrument, designed to integrate generic and disease specific measures, and includes both self- and proxy-reports. The aim of the study was to assess the reliability and limited validity of the Swedish version of the disease specific Pediatric Quality of Life Inventory 3.0 Cancer Module Scales (PedsQL 3.0), in a sample of Swedish children diagnosed with cancer.    Method  A total of 94 families at The Queen Silvia Children’s Hospital, Sahlgrenska University participated in the study. The Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQL 4.0) and the PedsQL 3.0 were administered to 63 children (aged 5–18 years) with cancer and to 94 parents of children with cancer aged 2–18 years.    Results  The internal consistency of the PedsQL 3.0, reached or exceeded Cronbach’s alpha values of 0.70 for both -self- and proxy-reports. The PedsQL 4.0 and PedsQL 3.0 were highly correlated ( r  = 0.94 for proxy-reports and r = 0.91 for self-reports), indicating convergent validity.    Conclusion  PedsQL 3.0 Cancer Module Scales can be used as a valuable tool for measuring cancer-specific HRQOL in child populations, both in research and in clinical practice.

The reliability of the health related quality of life questionnaire PedsQL 3.0 cancer module in a sample of Swedish children