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Background  We evaluated the role of  CYP3A5, ABCB1  and  SXR  gene polymorphisms in the occurrence of acute kidney rejection in a cohort of pediatric renal transplant recipients.    Methods  Forty-nine patients were genotyped for  CYP3A5, ABCB1  and  SXR  polymorphisms and evaluated with tacrolimus through levels in a retrospective monocenter study.    Results  Patients with the A allele of  CYP3A5  treated with tacrolimus had a higher risk of acute rejection than those without the A allele, while patients carrying the homozygous GG variant for  SXR A7635GG  did not show any episode of acute rejection.    Conclusion  Genetic analysis of polymorphisms implicated in drug metabolism and tacrolimus trough levels may help to forecast the risk of acute rejection and individualize drug dosage in children undergoing renal transplantation.

CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant