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Background   Glutathione S transferase  ( GST ) polymorphisms have been considered as risk factors for age-related cataracts, but the results remain controversial. In this study, we have performed a meta-analysis to evaluate the association between polymorphisms of  GSTM1  and  GSTT1  and cataract risk.    Methods  Published literature from PubMed and other databases were retrieved. The case–control studies regarding the association between  GSTM1  or  GSTT1  polymorphism and cataract risk were included. Pooled odds ratio (OR) and 95 % confidence interval (CI) were calculated using random- or fixed-effects model.    Results  Fifteen studies on  GSTM1  (3,065 patients and 2,105 controls), and nine studies on  GSTT1  (2,374 patients and 1,544 controls) were included. By pooling all the studies,  GSTM1  null polymorphism was not associated with cataract risk, and this negative association maintained in subgroup analyses. However,  GSTT1  null polymorphism was significantly associated with increased risk of posterior subcapsular (OR, 1.42; 95 % CI, 1.04–1.94) but not other subtypes of cataract. Stratified analyses demonstrated an association of  GSTT1  null genotype with increased risk of cataract in Asian (OR, 1.44; 95 % CI, 1.14–1.83) but not Caucasian populations. In addition, seven pooled studies showed no association of cataract risk with the combined  GSTM1  and  GSTT1  null genotypes.    Conclusions  This meta-analysis suggests that  GSTT1  null polymorphism is associated with increased risk of posterior subcapsular cataract. Given the limited sample size, the association between  GSTT1  null polymorphism and cataract risk in Asian awaits further investigation.

Is there association between Glutathione S Transferases polymorphisms and cataract risk: a meta-analysis?