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Background  The aim of this study was to analyze the frequencies of genotypes and alleles of Single Nucleotide Polymorphism (SNP)  LEP-R  c.668A>G  ( p.Gln223Arg, rs1137101) of leptin receptor gene and to assess the influence this DNA marker has on endometrial cancer (EC) with respect to total body fat content.    Methods  The study comprised 120 patients treated for endometrial cancer and 90 controls treated for uterine fibroids. In total, 210 patients were included in this research. DNA was isolated from archival post-operative specimens. Polymerase Chain Reaction – Restriction Fragment Length Polymorphism was employed to analyze the SNP.    Results  In this paper we have demonstrated that heterozygous genotype AG of SNP  LEP-R  c.668A>G  ( p.Gln223Arg, rs1137101) is statistically less frequent in women with endometrial cancer (EC) than in controls: 33  versus  57%, respectively. Similarly, this heterozygous genotype is statistically significantly less frequent in obese (BMI > 30) women with EC than in lean controls (BMI < 25): 30  versus  63%, respectively.    Conclusions  AG polymorphic variant of SNP  LEP-R  c.668A>G (p.Gln223Arg, rs1137101) in  LEP-R  may be considered a protective factor in the development of endometrial cancer.

Association of Single Nucleotide Polymorphism LEP-R c.668A>G (p.Gln223Arg, rs1137101) of leptin receptor gene with endometrial cancer