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Background  Supervised physical activity interventions improve functional health during cancer survivorship, but remain costly and inaccessible for many. We previously reported on the benefits of a DVD-delivered physical activity program ( FlexToBa™)  in older adults. This is a secondary analysis of the intervention effects among cancer survivors in the original sample.    Methods  Low active, older adults who self-reported a history of cancer ( N  = 46;  M  time since diagnosis = 10.7 ± 9.4 years) participated in a 6-month, home-based physical activity intervention. Participants were randomized to either the DVD-delivered physical activity program focused on flexibility, toning, and balance ( FlexToBa™ ;  n  = 22) or an attentional control condition ( n  = 24). Physical function was assessed by the Short Physical Performance Battery (SPPB) at baseline, end of intervention, and at 12 and 24 months after baseline.    Results  Repeated measures linear mixed models indicated a significant group*time interaction for the SPPB total score (β = − 1.14,  p  = 0.048), driven by improved function from baseline to six months in the  FlexToBa™  group. The intervention group also had improved balance (β = − 0.56,  p  = 0.041) compared with controls. Similar trends emerged for the SPPB total score during follow-up; the group*time interaction from 0 to 12 months approached significance (β = − 0.97,  p  = 0.089) and was significant from 0 to 24 months (β = − 1.84,  p  = 0.012). No significant interactions emerged for other outcomes ( p s > 0.11).    Conclusions  A DVD-delivered physical activity intervention designed for cancer-free older adults was capable of eliciting and maintaining clinically meaningful functional improvements in a subgroup of cancer survivors, with similar effects to the original full sample. These findings inform the dissemination of evidence-based physical activity programs during survivorship.    Trial registration   ClinicalTrials.gov  NCT01030419 . Registered 11 December 2009    Supplementary Information  The online version contains supplementary material available at 10.1186/s12885-021-08608-8.

Effects of a DVD-delivered randomized controlled physical activity intervention on functional health in cancer survivors